Endocrine Abstracts

Adrenocortical carcinoma (ACC) is a rare endocrine tumour with a generally poor prognosis. Mitotane is the only approved drug for treatment of advanced ACC (“palliative” setting). However, response is relatively poor with up to 20% of patients experiencing objective response (Megerle 2018). Moreover, adjuvant treatment with mitotane is frequently recommended for patients at high risk of disease recurrence after surgery (Terzolo 2007, Fassnacht 2018). Of note, mitotan...

Introduction: Unexplained weight loss is a cause for concern; it might indicate an underlying condition, usualy a catabolic state. In empty sella, the progressive loss of pituitary hormone secretion is usually a slow process, with symptoms varying from one person to another and depends on the underlying cause. Usually the weight remain relatively constant or we could have several arguments for weight gain.Case report: A 57 years old man with significant ...

Key learning points• Adrenocortical tumors comprise frequent benign adenomas and rare aggressive carcinomas (ACC).• cAMP/PKA pathway plays a central role in the pathogenesis of cortisol-producing adenomas - associated with Cushing syndrome, while molecular alterations in Wnt/β-catenin, Rb/p53 pathway and chromatin remodeling are frequent in ACCs.<p class="a...

The underlying basis for understanding of how brain control energy homeostasis, resides in a functional and coordinate communicating pathways between peripheral endocrine organs and the brain, in which the hypothalamus plays a pivotal role in the integration and processing of peripheral metabolic cues into satiety and feeding signals. Glial cells in particular astrocytes, as being an integral cell type of the neurovascular unit forming direct physical contacts with cerebral b...

Background: Graves disease is the most common cause of hyperthyroidism or thyrotoxicosis in children. The prevalance is 1 in 10 000 among children. It is important to reinforce the awareness amongst clinicians as patients can present with wide range of clinical symptoms. The range of presentations in our study included a child treated for one year for Attention Deficit Hyperactivity Disorder (ADHD) to a child who had diarrhoea and abdominal pain and presented as appendicitis i...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine system disorder among women of reproductive age. Although some studies have suggested an association between PCOS and autoimmune thyroiditis, only a few cases indicating association between PCOS and Graves’ disease are reported.Case report: We present a woman aged 29 with Graves' disease certified by suppressed TSH (0.001 mUI/l), high FT4 (6.6 ng/dl) associated with elevated TRAb (...

Background: Primary autoimmune hypophysitis (PAH) is a rare chronic inflammatory condition of the pituitary gland that occurs more commonly in females during pregnancy or in the post-partum period. It is strongly associated with other autoimmune disorders. The various forms of hypophysitis are misdiagnosed as pituitary adenoma in 40% cases.Objective: First of all, we propose to present a case of PAH associated with other autoimmune diseases. Our second a...

Normocalcemic primary hyperparathyroidism (NPH) is characterized by normal total and ionized serum calcium concentrations and consistently elevated PTH levels. These patients have no obvious causes for secondary elevations of PTH, such as renal disease, vitamin D deficiency or malnutrition. The group consisted of 22 postmenopausal women, six premenopausal women, and two men, aged 58±2 years (range 31–77) investigated between 2011 and 2016.Resul...

Introduction: Paget’s disease of bone (PDB) is the second-most-common metabolic bone disease, after osteoporosis, affecting about 3% of the population at age over 40 years. This disease is characterized by excessive and abnormal bone remodeling due to increased bone resorption followed by disorganized bone formation.This paper will include a case report and a review of PDB epidemiology and pathophysiology, complications and clinical findings, indica...

Thyroid disease is common among the population, and the prevalence increases with age. In patients with type 1 diabetes mellitus (T1DM) the risk of thyroid dysfunction and thyroid autoimmunity is increased. The aim of this study was to investigate the relationship between thyroid function and T1DM duration. There were evaluated 110 patients (71 women and 39 men) with T1DM between 2013 and 2015 and were appreciated antibodies against thyroid peroxidase (ATPO) (normal values...